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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GSK3A
All Species:
21.52
Human Site:
S370
Identified Species:
33.81
UniProt:
P49840
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49840
NP_063937.2
483
50981
S370
P
W
T
K
V
F
K
S
R
T
P
P
E
A
I
Chimpanzee
Pan troglodytes
XP_530044
483
51007
S370
P
W
T
K
V
F
K
S
R
T
P
P
E
A
I
Rhesus Macaque
Macaca mulatta
XP_001104964
483
50993
S370
P
W
T
K
V
F
K
S
R
T
P
P
E
A
I
Dog
Lupus familis
XP_852706
441
48143
S328
Q
G
R
R
V
F
K
S
R
T
P
P
E
A
I
Cat
Felis silvestris
Mouse
Mus musculus
Q2NL51
490
51642
S371
W
T
K
V
F
K
S
S
K
T
P
P
E
A
I
Rat
Rattus norvegicus
P18265
483
51008
S370
P
W
T
K
V
F
K
S
R
T
P
P
E
A
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416557
433
48108
R321
G
V
R
V
F
R
P
R
T
P
P
E
A
I
A
Frog
Xenopus laevis
NP_001083752
420
46885
A307
P
W
T
K
V
F
R
A
R
T
P
P
E
A
I
Zebra Danio
Brachydanio rerio
NP_001038386
462
50821
I350
T
E
F
K
F
P
Q
I
K
A
H
P
W
T
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18431
1067
114422
I858
P
W
Q
K
V
F
R
I
R
T
P
T
E
A
I
Honey Bee
Apis mellifera
XP_392504
434
48445
A322
R
A
R
T
P
P
E
A
M
E
L
V
A
G
L
Nematode Worm
Caenorhab. elegans
Q9U2Q9
362
40864
I250
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
S182
L
L
G
A
R
Q
Y
S
T
P
V
D
V
W
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8VZD5
410
46056
R296
K
V
L
G
T
P
T
R
E
E
I
K
C
M
N
Baker's Yeast
Sacchar. cerevisiae
P38615
370
42986
T258
E
I
I
K
I
L
G
T
P
S
K
Q
E
I
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99.7
85.5
N.A.
93.8
97
N.A.
N.A.
67.9
67.4
71.8
N.A.
33.4
64.1
55.2
N.A.
Protein Similarity:
100
99.7
99.7
86.3
N.A.
95.5
97.7
N.A.
N.A.
74.9
74.5
77.6
N.A.
38
75.1
63.7
N.A.
P-Site Identity:
100
100
100
73.3
N.A.
46.6
100
N.A.
N.A.
6.6
86.6
13.3
N.A.
73.3
0
6.6
N.A.
P-Site Similarity:
100
100
100
80
N.A.
53.3
100
N.A.
N.A.
6.6
100
26.6
N.A.
80
20
13.3
N.A.
Percent
Protein Identity:
N.A.
24.4
N.A.
52.8
40.7
N.A.
Protein Similarity:
N.A.
38.1
N.A.
63.7
55.4
N.A.
P-Site Identity:
N.A.
6.6
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
0
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
0
0
0
14
0
7
0
0
14
54
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
7
% C
% Asp:
0
7
0
0
0
0
0
0
0
0
0
7
0
0
0
% D
% Glu:
7
7
0
0
0
7
7
0
7
14
0
7
60
0
0
% E
% Phe:
0
0
7
0
20
47
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
7
7
7
0
0
7
0
0
0
0
7
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
7
7
0
7
0
7
20
0
0
7
0
0
14
54
% I
% Lys:
7
0
7
54
0
7
34
0
20
0
7
7
0
0
7
% K
% Leu:
7
7
7
7
0
7
0
0
0
0
14
0
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
7
0
0
0
0
7
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% N
% Pro:
40
0
0
0
7
20
7
0
7
14
60
54
0
7
0
% P
% Gln:
7
0
14
0
0
7
7
0
0
0
0
7
0
0
0
% Q
% Arg:
7
0
20
7
7
7
14
14
47
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
7
47
0
7
0
0
0
0
7
% S
% Thr:
7
7
34
7
7
0
7
7
14
54
0
7
7
7
7
% T
% Val:
7
14
0
14
54
0
0
0
0
7
7
7
7
0
0
% V
% Trp:
7
40
0
0
0
0
0
0
0
0
0
0
7
7
0
% W
% Tyr:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _